InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DBH

Summary

InnateDB Gene

IDBG-640798.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DBH

Gene Name

Dopamine beta-hydroxylase Soluble dopamine beta-hydroxylase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004508

Encoded Proteins

IDBP-693119

Dopamine beta-hydroxylaseSoluble dopamine beta-hydroxylase

IDBP-693122

Dopamine beta-hydroxylaseSoluble dopamine beta-hydroxylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123454:
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:104554824-104572619

Strand

Forward strand

Band

Transcripts

ENSBTAT00000005924	ENSBTAP00000005924
ENSBTAT00000055221	ENSBTAP00000047899

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0004500	dopamine beta-monooxygenase activity
GO:0005507	copper ion binding
GO:0016491	oxidoreductase activity
GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0031418	L-ascorbic acid binding
GO:0046872	metal ion binding

Biological Process

GO:0001816	cytokine production
GO:0001974	blood vessel remodeling
GO:0001975	response to amphetamine
GO:0002443	leukocyte mediated immunity
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0008306	associative learning
GO:0008542	visual learning
GO:0042127	regulation of cell proliferation
GO:0042309	homoiothermy
GO:0042420	dopamine catabolic process
GO:0042421	norepinephrine biosynthetic process
GO:0042423	catecholamine biosynthetic process
GO:0042593	glucose homeostasis
GO:0042596	fear response
GO:0042711	maternal behavior
GO:0045907	positive regulation of vasoconstriction
GO:0048149	behavioral response to ethanol
GO:0048265	response to pain
GO:0050900	leukocyte migration
GO:0055114	oxidation-reduction process
GO:2001236	regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030658	transport vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0034466	chromaffin granule lumen
GO:0042584	chromaffin granule membrane