InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PNKP

Summary

InnateDB Protein

IDBP-693172.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PNKP

Protein Name

bifunctional polynucleotide phosphatase/kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002397

InnateDB Gene

IDBG-640829 (PNKP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019201	nucleotide kinase activity
GO:0046403	polynucleotide 3'-phosphatase activity
GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity

Biological Process

GO:0006281	DNA repair
GO:0006979	response to oxidative stress
GO:0016311	dephosphorylation
GO:0042769	DNA damage response, detection of DNA damage
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006549 HAD-superfamily hydrolase,subfamily IIIA
IPR006550 Polynucleotide kinase 3-phosphatase, metazoan
IPR006551 Polynucleotide 3\'-phosphatase
IPR008984 SMAD/FHA domain
IPR013954 Polynucleotide kinase 3 phosphatase
IPR023214 HAD-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF08645
PF00702
PF08282
PF13419

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1N3Q9

UniProt Splice Variant

Entrez Gene

616621

UniGene

RefSeq

NP_001076991

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123660 DAAA02047486

GenPept

AAI23661