Version 5.4
Bos taurus Protein: SMARCAD1
Summary
InnateDB Protein IDBP-693411.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMARCAD1
Protein Name SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000045084
InnateDB Gene IDBG-641078 (SMARCAD1)
Protein Structure
UniProt Annotation
Function DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.
Predicted by orthology
Total 107 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0000729 DNA double-strand break processing
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0016568 chromatin modification
GO:0043044 ATP-dependent chromatin remodeling
GO:0051304 chromosome separation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005694 chromosome
GO:0035861 site of double-strand break
GO:0043596 nuclear replication fork
Protein Structure and Domains
PDB ID
InterPro IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR003892 Ubiquitin system component Cue
IPR006935 Helicase/UvrB domain
IPR009060 UBA-like
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00176
PF00271
PF02845
PF04851
PRINTS
PIRSF
SMART SM00490
SM00546
SM00487
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E1B7X9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 530506
UniGene
RefSeq NP_001192361
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02016925 DAAA02016926
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca