InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ADAMTS2

Summary

InnateDB Protein

IDBP-693464.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS2

Protein Name

A disintegrin and metalloproteinase with thrombospondin motifs 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019526

InnateDB Gene

IDBG-641136 (ADAMTS2)

Protein Structure

UniProt Annotation

Function

Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Note=Defects in ADAMTS2 are the cause of dermatosparaxis, a recessively inherited disorder characterized by severe skin fragility and biochemically by the presence in skin of procollagen incompletely processed at the N-terminus.

Tissue Specificity

Enzymatic activity is detected at high level in all type I collagen-rich tissues such as skin, bones, tendons and aorta and at low level in brain and thymus. The mRNA levels were disproportionately high in heart, liver, retina and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0007283	spermatogenesis
GO:0016485	protein processing
GO:0030199	collagen fibril organization
GO:0030324	lung development
GO:0030574	collagen catabolic process
GO:0032964	collagen biosynthetic process
GO:0043206	extracellular fibril organization
GO:0043588	skin development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR010294 ADAM-TS Spacer 1
IPR010909 PLAC
IPR013273 Peptidase M12B, ADAM-TS
IPR013275 Peptidase M12B, ADAM-TS2

PFAM

PF00090
PF01421
PF01562
PF05986
PF08686

PRINTS

PR01857
PR01859

PIRSF

SMART

SM00209

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt