Version 5.4
Bos taurus Protein: TRIM11
Summary
InnateDB Protein IDBP-693505.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM11
Protein Name E3 ubiquitin-protein ligase TRIM11
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024852
InnateDB Gene IDBG-641177 (TRIM11)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the nucleus, colocalizes with PAX6. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019904 protein domain specific binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0032897 negative regulation of viral transcription
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046597 negative regulation of viral entry into host cell
GO:0046598 positive regulation of viral entry into host cell
GO:0050768 negative regulation of neurogenesis
GO:0051607 defense response to virus
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF00643
PF13639
PF14634
PF00622
PF13765
PF00097
PRINTS PR01407
PIRSF
SMART SM00336
SM00184
SM00449
SM00589
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0JN74
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514580
UniGene Bt.34145
RefSeq NP_001071388
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126548
GenPept AAI26549

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca