Version 5.4
Bos taurus Protein: ZC3H12A
Summary
InnateDB Protein IDBP-693549.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZC3H12A
Protein Name Ribonuclease ZC3H12A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015041
InnateDB Gene IDBG-641215 (ZC3H12A)
Protein Structure
UniProt Annotation
Function Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250UniProtKB:Q5D1E8}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0007275 multicellular organismal development
GO:0008152 metabolic process
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010884 positive regulation of lipid storage
GO:0030154 cell differentiation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045600 positive regulation of fat cell differentiation
GO:0071222 cellular response to lipopolysaccharide
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR021869 Ribonuclease Zc3h12a-like
PFAM PF11977
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6QQJ8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 535344
UniGene Bt.8745
RefSeq NP_001095657
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149867
GenPept AAI49868

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca