InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ZC3H12A

Summary

InnateDB Gene

IDBG-641215.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZC3H12A

Gene Name

Ribonuclease ZC3H12A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011316

Encoded Proteins

IDBP-693549

Ribonuclease ZC3H12A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22037600

[Homo sapiens] ZC3H12A prevents autoimmunity by controlling the stability of cytokine mRNA, such as IL6. ZC3H12A protein degradation is facilitated by IKK complex, which acts downstream of TLR stimulation. (Demonstrated in mice)

PMID 22777400

[Homo sapiens] ZC3H12A is a potent regulator of innate immunity, which can be strongly engaged in the pathogenesis of acute and chronic infective diseases.

PMID 22037600

[Mus musculus] Zc3h12a prevents autoimmunity by controlling the stability of cytokine mRNA, such as Il6. Zc3h12a protein degradation is facilitated by IKK complex, which acts downstream of TLR stimulation.

PMID 22777400

[Mus musculus] Zc3h12a is a potent regulator of innate immunity, which can be strongly engaged in the pathogenesis of acute and chronic infective diseases. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163874:
ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:108990074-108999453

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015041

ENSBTAP00000015041

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptotic process
GO:0007275	multicellular organismal development
GO:0008152	metabolic process
GO:0010508	positive regulation of autophagy
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010884	positive regulation of lipid storage
GO:0030154	cell differentiation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045600	positive regulation of fat cell differentiation
GO:0071222	cellular response to lipopolysaccharide
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000163874

View Gene Order

ENSMUSG00000042677

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.8745

RefSeq

NM_001102187 XM_005204793

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas