Version 5.4
Bos taurus Protein: LFNG
Summary
InnateDB Protein IDBP-693630.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LFNG
Protein Name Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000052963
InnateDB Gene IDBG-641284 (LFNG)
Protein Structure
UniProt Annotation
Function Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0001541 ovarian follicle development
GO:0001756 somitogenesis
GO:0007143 female meiotic division
GO:0007275 multicellular organismal development
GO:0007386 compartment pattern specification
GO:0007389 pattern specification process
GO:0008152 metabolic process
GO:0008593 regulation of Notch signaling pathway
GO:0014807 regulation of somitogenesis
GO:0032092 positive regulation of protein binding
GO:0045747 positive regulation of Notch signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID
InterPro IPR003378 Fringe-like
IPR017374 Fringe
PFAM PF02434
PRINTS
PIRSF PIRSF038073
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KJ92
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 516209
UniGene Bt.11476
RefSeq NP_001039687
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105463
GenPept AAI05464

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca