InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LFNG

Summary

InnateDB Gene

IDBG-641284.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LFNG

Gene Name

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000040361

Encoded Proteins

IDBP-693630

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106003:
This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:41304501-41313035

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000056003

ENSBTAP00000052963

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0001541	ovarian follicle development
GO:0001756	somitogenesis
GO:0007143	female meiotic division
GO:0007275	multicellular organismal development
GO:0007386	compartment pattern specification
GO:0007389	pattern specification process
GO:0008152	metabolic process
GO:0008593	regulation of Notch signaling pathway
GO:0014807	regulation of somitogenesis
GO:0032092	positive regulation of protein binding
GO:0045747	positive regulation of Notch signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane