InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDEM2

Summary

InnateDB Protein

IDBP-69373.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDEM2

Protein Name

ER degradation enhancer, mannosidase alpha-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363616

InnateDB Gene

IDBG-69371 (EDEM2)

Protein Structure

UniProt Annotation

Function

Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. {ECO:0000269PubMed:15537790, ECO:0000269PubMed:15579471}.

Subcellular Localization

Secreted. Endoplasmic reticulum lumen.

Disease Associations

Tissue Specificity

Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle. {ECO:0000269PubMed:15537790}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding

Biological Process

GO:0006457	protein folding
GO:0006986	response to unfolded protein
GO:0008152	metabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process