Version 5.4
Homo sapiens Gene: EDEM2
Summary
InnateDB Gene IDBG-69371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDEM2
Gene Name ER degradation enhancer, mannosidase alpha-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000088298
Encoded Proteins
IDBP-69373
ER degradation enhancer, mannosidase alpha-like 2
IDBP-69375
ER degradation enhancer, mannosidase alpha-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:35115357-35147364
Strand Reverse strand
Band q11.22
Transcripts
ENST00000374492 ENSP00000363616
ENST00000374491 ENSP00000363615
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006457 protein folding
GO:0006986 response to unfolded protein
GO:0008152 metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038312
View Gene Order
ENSBTAG00000003815
Not yet available
Pathways
NETPATH
REACTOME
REACT_25091
ER Quality Control Compartment (ERQC) pathway
REACT_23810
Calnexin/calreticulin cycle pathway
REACT_23878
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9BV94
TrEMBL B4E1F4
UniProt Splice Variant
Entrez Gene 55741
UniGene Hs.720177
RefSeq NM_001145025 NM_018217
HUGO HGNC:15877
OMIM 610302
CCDS CCDS13247 CCDS46592
HPRD
IMGT
EMBL AK001645 AK023931 AK300212 AK303816 AL121753 AL135844 AL356652 AY358580 BC001371 BC016184 CH471077 CR457266
GenPept AAH01371 AAH16184 AAQ88943 BAA91806 BAB14731 BAG61981 BAG64766 CAG33547 CAH73763 CAI19292 EAW76228
RNA Seq Atlas 55741

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca