InnateDB Protein
|
IDBP-69375.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
EDEM2
|
Protein Name
|
ER degradation enhancer, mannosidase alpha-like 2
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000363615
|
InnateDB Gene
|
IDBG-69371 (EDEM2)
|
Protein Structure
|
|
Function |
Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. {ECO:0000269PubMed:15537790, ECO:0000269PubMed:15579471}.
|
Subcellular Localization |
Secreted. Endoplasmic reticulum lumen.
|
Disease Associations |
|
Tissue Specificity |
Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle. {ECO:0000269PubMed:15537790}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0004571
|
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
|
GO:0005509
|
calcium ion binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001382
Glycoside hydrolase, family 47
|
PFAM |
PF01532
|
PRINTS |
PR00747
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9BV94
|
PhosphoSite |
PhosphoSite-Q9BV94
|
TrEMBL |
B4E1F4
|
UniProt Splice Variant |
|
Entrez Gene |
55741
|
UniGene |
Hs.720177
|
RefSeq |
NP_001138497
|
HUGO |
HGNC:15877
|
OMIM |
610302
|
CCDS |
CCDS46592
|
HPRD |
09841
|
IMGT |
|
EMBL |
AK001645
AK023931
AK300212
AK303816
AL121753
AL135844
AL356652
AY358580
BC001371
BC016184
CH471077
CR457266
|
GenPept |
AAH01371
AAH16184
AAQ88943
BAA91806
BAB14731
BAG61981
BAG64766
CAG33547
CAH73763
CAI19292
EAW76228
|
|
|