InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LGALS1

Summary

InnateDB Protein

IDBP-693806.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGALS1

Protein Name

Galectin-1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020080

InnateDB Gene

IDBG-641441 (LGALS1)

Protein Structure

UniProt Annotation

Function

May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity. Strong inducer of T-cell apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016936	galactoside binding
GO:0030246	carbohydrate binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002317	plasma cell differentiation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0031295	T cell costimulation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045445	myoblast differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome