InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACVR1C

Summary

InnateDB Protein

IDBP-693985.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVR1C

Protein Name

activin A receptor, type IC

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025753

InnateDB Gene

IDBG-641609 (ACVR1C)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016361	activin receptor activity, type I
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0038100	nodal binding

Biological Process

GO:0002021	response to dietary excess
GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009749	response to glucose
GO:0016310	phosphorylation
GO:0019915	lipid storage
GO:0023014	signal transduction by phosphorylation
GO:0030154	cell differentiation
GO:0030262	apoptotic nuclear changes
GO:0032868	response to insulin
GO:0038092	nodal signaling pathway
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046676	negative regulation of insulin secretion
GO:1901164	negative regulation of trophoblast cell migration
GO:1901383	negative regulation of chorionic trophoblast cell proliferation

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048179	activin receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003605 TGF beta receptor, GS motif
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01064
PF00069
PF07714
PF08515

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00467
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt