InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACVR1C

Summary

InnateDB Gene

IDBG-641609.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVR1C

Gene Name

activin receptor type-1C precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019337

Encoded Proteins

IDBP-693985

activin A receptor, type IC

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123612:
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:38549887-38599514

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025753

ENSBTAP00000025753

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016361	activin receptor activity, type I
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0038100	nodal binding

Biological Process

GO:0002021	response to dietary excess
GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009749	response to glucose
GO:0016310	phosphorylation
GO:0019915	lipid storage
GO:0023014	signal transduction by phosphorylation
GO:0030154	cell differentiation
GO:0030262	apoptotic nuclear changes
GO:0032868	response to insulin
GO:0038092	nodal signaling pathway
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046676	negative regulation of insulin secretion
GO:1901164	negative regulation of trophoblast cell migration
GO:1901383	negative regulation of chorionic trophoblast cell proliferation