InnateDB Protein
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IDBP-69422.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EXOC7
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Protein Name
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exocyst complex component 7
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Synonyms
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2-5-3p; EX070; EXO70; Exo70p; EXOC1; YJL085W;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000333806
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InnateDB Gene
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IDBG-69418 (EXOC7)
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Protein Structure
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Function |
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
32
[view]
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Protein-Protein |
32
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004140
Exocyst complex protein Exo70
IPR016159
Cullin repeat-like-containing domain
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PFAM |
PF03081
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UPT5
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PhosphoSite |
PhosphoSite-Q9UPT5
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TrEMBL |
C9JME6
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UniProt Splice Variant |
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Entrez Gene |
23265
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UniGene |
Hs.734508
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RefSeq |
NP_056034
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HUGO |
HGNC:23214
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OMIM |
608163
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CCDS |
CCDS11741
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HPRD |
16292
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IMGT |
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EMBL |
AB028990
AC018665
AK022397
AK022552
AK023832
AL834324
BC011045
BC018466
FJ457119
FJ457120
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GenPept |
AAH11045
AAH18466
ACK36853
ACK36854
BAA83019
BAB14026
BAB14095
BAB14694
CAD38992
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