InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NOX4

Summary

InnateDB Protein

IDBP-694255.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOX4

Protein Name

NADPH oxidase 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024676

InnateDB Gene

IDBG-641834 (NOX4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0072341	modified amino acid binding

Biological Process

GO:0000902	cell morphogenesis
GO:0007569	cell aging
GO:0008285	negative regulation of cell proliferation
GO:0042554	superoxide anion generation
GO:0043406	positive regulation of MAP kinase activity
GO:0045453	bone resorption
GO:0050667	homocysteine metabolic process
GO:0051897	positive regulation of protein kinase B signaling
GO:0055007	cardiac muscle cell differentiation
GO:0055114	oxidation-reduction process
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071333	cellular response to glucose stimulus
GO:0072593	reactive oxygen species metabolic process
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite