InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NOX4

Summary

InnateDB Gene

IDBG-641834.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOX4

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018540

Encoded Proteins

IDBP-694255

NADPH oxidase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18511861

[Homo sapiens] NOX4 is implicated in innate immunity since lipopolysaccharide (LPS) induces NOX4-dependent reactive oxygen species (ROS) generation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000086991:
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:6147990-6326526

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024676

ENSBTAP00000024676

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0072341	modified amino acid binding

Biological Process

GO:0000902	cell morphogenesis
GO:0007569	cell aging
GO:0008285	negative regulation of cell proliferation
GO:0042554	superoxide anion generation
GO:0043406	positive regulation of MAP kinase activity
GO:0045453	bone resorption
GO:0050667	homocysteine metabolic process
GO:0051897	positive regulation of protein kinase B signaling
GO:0055007	cardiac muscle cell differentiation
GO:0055114	oxidation-reduction process
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071333	cellular response to glucose stimulus
GO:0072593	reactive oxygen species metabolic process
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000086991

View Gene Order

ENSMUSG00000030562

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

ptp1bpathway

Signaling events mediated by PTP1B

Cross-References

SwissProt

TrEMBL

F1MQX5

UniProt Splice Variant

Entrez Gene

378474

UniGene

Bt.23582

RefSeq

XM_002699032 XM_614713

HUGO

HGNC:7891

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02062455 DAAA02062456 DAAA02062457 DAAA02062458 DAAA02062459

GenPept

RNA Seq Atlas

378474