InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EXOC7

Summary

InnateDB Protein

IDBP-69426.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXOC7

Protein Name

exocyst complex component 7

Synonyms

2-5-3p; EX070; EXO70; Exo70p; EXOC1; YJL085W;

Species

Homo sapiens

Ensembl Protein

ENSP00000334100

InnateDB Gene

IDBG-69418 (EXOC7)

Protein Structure

UniProt Annotation

Function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006887	exocytosis
GO:0015031	protein transport
GO:0044267	cellular protein metabolic process
GO:0061024	membrane organization

Cellular Component

GO:0000145	exocyst
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032584	growth cone membrane
GO:0034451	centriolar satellite