Version 5.4
Bos taurus Protein: AHCY
Summary
InnateDB Protein IDBP-694293.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AHCY
Protein Name Adenosylhomocysteinase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024092
InnateDB Gene IDBG-641883 (AHCY)
Protein Structure
UniProt Annotation
Function Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004013 adenosylhomocysteinase activity
GO:0004455 ketol-acid reductoisomerase activity
GO:0005507 copper ion binding
GO:0016787 hydrolase activity
GO:0043621 protein self-association
GO:0051287 NAD binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0019510 S-adenosylhomocysteine catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000043 Adenosylhomocysteinase
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
IPR013116 Acetohydroxy acid isomeroreductase, catalytic
IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PFAM PF05221
PF02826
PF07991
PF00670
PRINTS
PIRSF PIRSF001109
SMART SM00996
SM00997
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MHL4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508158
UniGene Bt.12322
RefSeq NP_001029487
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105194 BT030537
GenPept AAI05195 ABQ12977

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca