Version 5.4
Bos taurus Protein: SAG
Summary
InnateDB Protein IDBP-694294.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAG
Protein Name S-arrestinS-arrestin short form
Synonyms S-AG;
Species Bos taurus
Ensembl Protein ENSBTAP00000028633
InnateDB Gene IDBG-641875 (SAG)
Protein Structure
UniProt Annotation
Function Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Isoform B plays a role in the phototransduction cascade.
Subcellular Localization
Disease Associations Note=S-antigen induces autoimmune uveitis.
Tissue Specificity Retina and pineal gland. Isoform B is localized in the photoreceptor outer segment.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002046 opsin binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0050896 response to stimulus
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000698 Arrestin
IPR011021 Arrestin-like, N-terminal
IPR011022 Arrestin C-terminal-like domain
IPR014756 Immunoglobulin E-set
PFAM PF00339
PF02752
PRINTS PR00309
PIRSF
SMART SM01017
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P08168
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280922
UniGene Bt.32317
RefSeq XP_005205002
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL J02955 M15115 U08346 X03454
GenPept AAA20465 AAA30377 AAA30378 CAA27179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca