InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ITCH

Summary

InnateDB Protein

IDBP-694308.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITCH

Protein Name

itchy homolog E3 ubiquitin protein ligase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000397

InnateDB Gene

IDBG-641890 (ITCH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.

Predicted by orthology
Total	107 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0043021	ribonucleoprotein complex binding
GO:0045236	CXCR chemokine receptor binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0002669	positive regulation of T cell anergy
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0035519	protein K29-linked ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0045732	positive regulation of protein catabolic process
GO:0046329	negative regulation of JNK cascade
GO:0046642	negative regulation of alpha-beta T cell proliferation
GO:0050687	negative regulation of defense response to virus
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0090085	regulation of protein deubiquitination