Version 5.4
Bos taurus Gene: ITCH
Summary
InnateDB Gene IDBG-641890.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITCH
Gene Name E3 ubiquitin-protein ligase Itchy homolog
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000308
Encoded Proteins
IDBP-694308
itchy homolog E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18246070
[Homo sapiens] ITCH is an E3 ligase that negatively regulates inflammatory signalling pathways by controlling the function of the ubiquitin-editing enzyme TNFAIP3.
PMID 19881509
[Homo sapiens] ITCH is a HECT domain-containing E3 ligase that negatively regulates MAVS-mediated antiviral response by catalyzing the K48-linked polyubiquitination and degradation of MAVS.
PMID 22057290
[Homo sapiens] The E3 ligase ITCH and deubiquitinase CYLD act together to regulate TAK1 and inflammation.
PMID 22057290
[Mus musculus] The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078747:
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:64357862-64462219
Strand Forward strand
Band
Transcripts
ENSBTAT00000000397 ENSBTAP00000000397
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.
Predicted by orthology
Total 107 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0043021 ribonucleoprotein complex binding
GO:0045236 CXCR chemokine receptor binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002669 positive regulation of T cell anergy
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0035519 protein K29-linked ubiquitination
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0045732 positive regulation of protein catabolic process
GO:0046329 negative regulation of JNK cascade
GO:0046642 negative regulation of alpha-beta T cell proliferation
GO:0050687 negative regulation of defense response to virus
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0090085 regulation of protein deubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000078747
View Gene Order
ENSMUSG00000027598
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_115828
Downregulation of ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_6802
Innate Immune System pathway
REACT_267605
Degradation of GLI1 by the proteasome pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_189085
Disease pathway
REACT_269412
Hedgehog 'off' state pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_198532
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_230745
Immune System pathway
REACT_199100
Downregulation of ERBB4 signaling pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199384
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_268705
Degradation of GLI1 by the proteasome pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_211125
NOD1/2 Signaling Pathway pathway
REACT_229531
Adaptive Immune System pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_231152
Signaling by NOTCH pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04144
Endocytosis pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04144
Endocytosis pathway
INOH
INOH website
TNFR1 signaling pathway pathway
INOH website
TNFR1 signaling pathway pathway
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
erbb4_pathway
ErbB4 signaling events
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
p73pathway
p73 transcription factor network
tgfbrpathway
TGF-beta receptor signaling
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
tap63pathway
Validated transcriptional targets of TAp63 isoforms
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL F1MGQ5
UniProt Splice Variant
Entrez Gene 508431
UniGene Bt.8905
RefSeq NM_001082428
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036500 DAAA02036501 DAAA02036502 DAAA02036503 DAAA02036504 DAAA02036505 DAAA02036506
GenPept
RNA Seq Atlas 508431

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca