InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACO2

Summary

InnateDB Protein

IDBP-694324.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACO2

Protein Name

Aconitate hydratase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008431

InnateDB Gene

IDBG-641912 (ACO2)

Protein Structure

UniProt Annotation

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003994	aconitate hydratase activity
GO:0005506	iron ion binding
GO:0016829	lyase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006101	citrate metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel
IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
IPR006248 Aconitase, mitochondrial-like
IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel

PFAM

PF00694
PF00330

PRINTS

PR00415

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20004