Version 5.4
Bos taurus Protein: PICALM
Summary
InnateDB Protein IDBP-694336.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PICALM
Protein Name phosphatidylinositol-binding clathrin assembly protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002170
InnateDB Gene IDBG-641926 (PICALM)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005545 1-phosphatidylinositol binding
GO:0030276 clathrin binding
GO:0032050 clathrin heavy chain binding
GO:0035615 clathrin adaptor activity
Biological Process
GO:0007409 axonogenesis
GO:0008283 cell proliferation
GO:0010629 negative regulation of gene expression
GO:0016188 synaptic vesicle maturation
GO:0016197 endosomal transport
GO:0030097 hemopoiesis
GO:0030100 regulation of endocytosis
GO:0031623 receptor internalization
GO:0032880 regulation of protein localization
GO:0035459 cargo loading into vesicle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0048268 clathrin coat assembly
GO:0048813 dendrite morphogenesis
GO:0055072 iron ion homeostasis
GO:0072583 clathrin-mediated endocytosis
GO:0097459 iron ion import into cell
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of beta-amyloid formation
GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0016020 membrane
GO:0030118 clathrin coat
GO:0030122 AP-2 adaptor complex
GO:0030132 clathrin coat of coated pit
GO:0031982 vesicle
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0097418 neurofibrillary tangle
Protein Structure and Domains
PDB ID
InterPro IPR001026 Epsin domain, N-terminal
IPR008942 ENTH/VHS
IPR011417 AP180 N-terminal homology (ANTH) domain
IPR013809 Epsin-like, N-terminal
PFAM PF01417
PF07651
PRINTS
PIRSF
SMART SM00273
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1N605
UniProt Splice Variant
Entrez Gene 513579
UniGene Bt.7758
RefSeq NP_001095447
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02062547 DAAA02062548
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca