InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PICALM

Summary

InnateDB Gene

IDBG-641926.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PICALM

Gene Name

phosphatidylinositol-binding clathrin assembly protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001657

Encoded Proteins

IDBP-694336

phosphatidylinositol-binding clathrin assembly protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073921:
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:9613012-9665840

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002170

ENSBTAP00000002170

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0005545	1-phosphatidylinositol binding
GO:0030276	clathrin binding
GO:0032050	clathrin heavy chain binding
GO:0035615	clathrin adaptor activity

Biological Process

GO:0007409	axonogenesis
GO:0008283	cell proliferation
GO:0010629	negative regulation of gene expression
GO:0016188	synaptic vesicle maturation
GO:0016197	endosomal transport
GO:0030097	hemopoiesis
GO:0030100	regulation of endocytosis
GO:0031623	receptor internalization
GO:0032880	regulation of protein localization
GO:0035459	cargo loading into vesicle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0048268	clathrin coat assembly
GO:0048813	dendrite morphogenesis
GO:0055072	iron ion homeostasis
GO:0072583	clathrin-mediated endocytosis
GO:0097459	iron ion import into cell
GO:1901216	positive regulation of neuron death
GO:1902004	positive regulation of beta-amyloid formation
GO:1902959	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0016020	membrane
GO:0030118	clathrin coat
GO:0030122	AP-2 adaptor complex
GO:0030132	clathrin coat of coated pit
GO:0031982	vesicle
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0097418	neurofibrillary tangle