InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: XRCC6

Summary

InnateDB Protein

IDBP-694341.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRCC6

Protein Name

X-ray repair complementing defective repair in Chinese hamster cells 6

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008020

InnateDB Gene

IDBG-641933 (XRCC6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 200 interaction(s) predicted by orthology.

Predicted by orthology
Total	200 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042162	telomeric DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity

Biological Process

GO:0000723	telomere maintenance
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006974	cellular response to DNA damage stimulus
GO:0010212	response to ionizing radiation
GO:0032508	DNA duplex unwinding
GO:0033151	V(D)J recombination
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050769	positive regulation of neurogenesis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0043564	Ku70:Ku80 complex
GO:0070419	nonhomologous end joining complex

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR003034 SAP domain
IPR005160 Ku70/Ku80 C-terminal arm
IPR005161 Ku70/Ku80, N-terminal alpha/beta
IPR006164 Ku70/Ku80 beta-barrel domain
IPR006165 Ku70
IPR016194 SPOC like C-terminal domain

PFAM

PF00092
PF02037
PF03730
PF03731
PF02735

PRINTS

PIRSF

PIRSF003033

SMART

SM00327
SM00513
SM00559

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt