Bos taurus Gene: XRCC6 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-641933.3 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | XRCC6 | ||||||||||||||||||||||||
Gene Name | X-ray repair cross-complementing protein 6 | ||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000006103 | ||||||||||||||||||||||||
Encoded Proteins |
X-ray repair complementing defective repair in Chinese hamster cells 6
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
Summary |
[Homo sapiens] Vaccinia virus protein C16 influences the immune response by binding to the XRCC6/XRCC5 (Ku70/80) complex thus blocking PRKDC-dependent DNA sensing in fibroblasts
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Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196419:
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 5:113228164-113251362 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | |||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 200 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
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REACTOME |
STING mediated induction of host immune responses pathway
2-LTR circle formation pathway
Integration of provirus pathway
Early Phase of HIV Life Cycle pathway
Processing of DNA ends prior to end rejoining pathway
Nonhomologous End-joining (NHEJ) pathway
IRF3-mediated induction of type I IFN pathway
Innate Immune System pathway
Double-Strand Break Repair pathway
Immune System pathway
HIV Life Cycle pathway
HIV Infection pathway
Cytosolic sensors of pathogen-associated DNA pathway
Disease pathway
DNA Repair pathway
Innate Immune System pathway
Double-Strand Break Repair pathway
Immune System pathway
Nonhomologous End-joining (NHEJ) pathway
DNA Repair pathway
IRF3-mediated induction of type I IFN pathway
Cytosolic sensors of pathogen-associated DNA pathway
STING mediated induction of host immune responses pathway
Processing of DNA ends prior to end rejoining pathway
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KEGG |
Non-homologous end-joining pathway
Non-homologous end-joining pathway
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INOH | |||||||||||||||||||||||||
PID NCI |
Coregulation of Androgen receptor activity
Signaling events mediated by HDAC Class III
BARD1 signaling events
DNA-PK pathway in nonhomologous end joining
Regulation of Telomerase
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Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | F1MMD5 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 510132 | ||||||||||||||||||||||||
UniGene | Bt.8019 | ||||||||||||||||||||||||
RefSeq | NM_001192246 XM_005207382 XM_005207383 XM_005207384 | ||||||||||||||||||||||||
HUGO | HGNC:4055 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | DAAA02014735 DAAA02014736 | ||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | 510132 | ||||||||||||||||||||||||