Version 5.4
Homo sapiens Protein: CREM
Summary
InnateDB Protein IDBP-69436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREM
Protein Name cAMP responsive element modulator
Synonyms CREM-2; hCREM-2; ICER;
Species Homo sapiens
Ensembl Protein ENSP00000363860
InnateDB Gene IDBG-69430 (CREM)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 27 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008140 cAMP response element binding protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001630 cAMP response element binding (CREB) protein
IPR003102 Coactivator CBP, pKID
IPR004827 Basic-leucine zipper domain
PFAM PF02173
PF00170
PF07716
PRINTS PR00041
PIRSF
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q03060
PhosphoSite PhosphoSite-Q03060
TrEMBL E9PB41
UniProt Splice Variant
Entrez Gene 1390
UniGene Hs.713133
RefSeq NP_898883
HUGO HGNC:2352
OMIM 123812
CCDS CCDS7183
HPRD 00444
IMGT
EMBL AF069065 AF212158 AF213897 AF213898 AF213899 AF214665 AF217318 AF417234 AK289379 AK290612 AK291566 AK301906 AL117336 AL157783 AY292864 BC017117 BC066342 BC090051 CH471072 D14825 D14826 S68134 S68271 U44836 Z15159
GenPept AAB03751 AAC19383 AAC60616 AAC60617 AAF66158 AAF68266 AAF68682 AAH17117 AAH66342 AAH90051 AAN32656 AAP44115 BAA03562 BAA03564 BAA03565 BAA03566 BAA03567 BAF82068 BAF83301 BAF84255 BAG63333 CAA78858 EAW85917 EAW85918

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca