InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CNGA1

Summary

InnateDB Protein

IDBP-694490.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNGA1

Protein Name

cGMP-gated cation channel alpha-1

Synonyms

CNCG1; CNG;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002853

InnateDB Gene

IDBG-642069 (CNGA1)

Protein Structure

UniProt Annotation

Function

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Rod cells in the retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005223	intracellular cGMP activated cation channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0030553	cGMP binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0042391	regulation of membrane potential
GO:0050896	response to stimulus
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042622	photoreceptor outer segment membrane
GO:1902495	transmembrane transporter complex

Protein Structure and Domains

PDB ID

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR005821 Ion transport domain
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF00520

PRINTS

PIRSF

SMART

SM00100

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q00194

PhosphoSite

PhosphoSite-Q00194

TrEMBL

UniProt Splice Variant

Entrez Gene

281700

UniGene

Bt.53

RefSeq

NP_776703

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

X51604

GenPept

CAA35947