InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CNGA1

Summary

InnateDB Gene

IDBG-642069.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNGA1

Gene Name

cGMP-gated cation channel alpha-1

Synonyms

CNCG1; CNG

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002205

Encoded Proteins

IDBP-694490

cGMP-gated cation channel alpha-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198515:
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:68316337-68354288

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002853

ENSBTAP00000002853

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005223	intracellular cGMP activated cation channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0030553	cGMP binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0042391	regulation of membrane potential
GO:0050896	response to stimulus
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042622	photoreceptor outer segment membrane
GO:1902495	transmembrane transporter complex