Version 5.4
Bos taurus Protein: ORC4
Summary
InnateDB Protein IDBP-694521.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORC4
Protein Name Origin recognition complex subunit 4
Synonyms ORC4L;
Species Bos taurus
Ensembl Protein ENSBTAP00000020335
InnateDB Gene IDBG-642098 (ORC4)
Protein Structure
UniProt Annotation
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005664 nuclear origin of replication recognition complex
Protein Structure and Domains
PDB ID
InterPro IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR011579 ATPase domain, prokaryote
IPR016527 Origin recognition complex, subunit 4
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00004
PF07724
PF13304
PF01637
PRINTS
PIRSF PIRSF007858
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2YDI2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 529245
UniGene Bt.13189
RefSeq NP_001039766
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC110211
GenPept AAI10212

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca