Version 5.4
Bos taurus Protein: PROCR
Summary
InnateDB Protein IDBP-694565.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROCR
Protein Name Endothelial protein C receptor
Synonyms EPCR;
Species Bos taurus
Ensembl Protein ENSBTAP00000010911
InnateDB Gene IDBG-642142 (PROCR)
Protein Structure
UniProt Annotation
Function Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed in endothelial cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0019882 antigen processing and presentation
GO:0050819 negative regulation of coagulation
Cellular Component
GO:0005813 centrosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR011162 MHC classes I/II-like antigen recognition protein
PFAM PF00129
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28105
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282005
UniGene Bt.526
RefSeq NP_776862
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116074 L39065
GenPept AAA87356 AAI16075

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca