InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PROCR

Summary

InnateDB Gene

IDBG-642142.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROCR

Gene Name

Endothelial protein C receptor

Synonyms

EPCR

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008291

Encoded Proteins

IDBP-694565

Endothelial protein C receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20543103

[Homo sapiens] PROCR confers anti-inflammatory properties when bound by activated protein C and when PROCR (EPCR) is blocked, F. tularensis loses the ability to suppress the pro-inflammatory response of endothelial cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101000:
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:65052810-65106553

Strand

Forward strand

Band

Transcripts

ENSBTAT00000010911

ENSBTAP00000010911

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0019882	antigen processing and presentation
GO:0050819	negative regulation of coagulation