Version 5.4
Bos taurus Protein: TSPO
Summary
InnateDB Protein IDBP-694571.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPO
Protein Name translocator protein
Synonyms BZRP;
Species Bos taurus
Ensembl Protein ENSBTAP00000024060
InnateDB Gene IDBG-642147 (TSPO)
Protein Structure
UniProt Annotation
Function Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1649835). {ECO:0000250, ECO:0000269PubMed:1649835}.
Subcellular Localization Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Membrane {ECO:0000269PubMed:1649835}; Multi-pass membrane protein {ECO:0000269PubMed:1649835}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0031966 mitochondrial membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004307 TspO/MBR-related protein
PFAM PF03073
PRINTS
PIRSF PIRSF005859
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30535
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281033
UniGene Bt.49341
RefSeq NP_786970
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102933 M64520
GenPept AAA30686 AAI02934

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca