Version 5.4
Bos taurus Protein: EIF6
Summary
InnateDB Protein IDBP-694573.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF6
Protein Name Eukaryotic translation initiation factor 6
Synonyms ITGB4BP;
Species Bos taurus
Ensembl Protein ENSBTAP00000014966
InnateDB Gene IDBG-642148 (EIF6)
Protein Structure
UniProt Annotation
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. {ECO:0000255HAMAP-Rule:MF_03132}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03132}. Nucleus, nucleolus {ECO:0000255HAMAP-Rule:MF_03132}. Note=Shuttles between cytoplasm and nucleus/nucleolus. {ECO:0000255HAMAP-Rule:MF_03132}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 134 interaction(s) predicted by orthology.
Predicted by orthology
Total 134 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
GO:0043023 ribosomal large subunit binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0006412 translation
GO:0006413 translational initiation
GO:0042256 mature ribosome assembly
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005638 lamin filament
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002769 Translation initiation factor IF6
PFAM PF01912
PRINTS
PIRSF PIRSF006413
SMART SM00654
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9TU47
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 286811
UniGene Bt.4426
RefSeq NP_777255
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF141872 BC109922
GenPept AAF00595 AAI09923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca