InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PROCR

Summary

InnateDB Protein

IDBP-69470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROCR

Protein Name

protein C receptor, endothelial

Synonyms

CCCA; CCD41; EPCR;

Species

Homo sapiens

Ensembl Protein

ENSP00000216968

InnateDB Gene

IDBG-69466 (PROCR)

Protein Structure

UniProt Annotation

Function

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007596	blood coagulation
GO:0019882	antigen processing and presentation
GO:0045087	innate immune response (InnateDB)
GO:0050819	negative regulation of coagulation