Version 5.4
| Homo sapiens Gene: PROCR | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-69466.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PROCR | ||||||||||||||||||
| Gene Name | protein C receptor, endothelial | ||||||||||||||||||
| Synonyms | CCCA; CCD41; EPCR | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000101000 | ||||||||||||||||||
| Encoded Proteins |
protein C receptor, endothelial
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
PROCR confers anti-inflammatory properties when bound by activated protein C and when PROCR (EPCR) is blocked, F. tularensis loses the ability to suppress the pro-inflammatory response of endothelial cells.
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| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 20:35172073-35177362 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q11.22 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Cell surface interactions at the vascular wall pathway
Common Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Hemostasis pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9UNN8 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 10544 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_006404 XM_006723682 | ||||||||||||||||||
| HUGO | HGNC:9452 | ||||||||||||||||||
| OMIM | 600646 | ||||||||||||||||||
| CCDS | CCDS13248 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB026584 AF106202 AF375468 AK314887 AL356652 BC014451 CH471077 CR456948 L35545 X89079 | ||||||||||||||||||
| GenPept | AAA63647 AAD43967 AAH14451 AAK53045 BAA77249 BAG37401 CAA61450 CAC16283 CAG33229 EAW76224 | ||||||||||||||||||
| RNA Seq Atlas | 10544 | ||||||||||||||||||