InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACMSD

Summary

InnateDB Protein

IDBP-694709.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACMSD

Protein Name

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010575

InnateDB Gene

IDBG-642268 (ACMSD)

Protein Structure

UniProt Annotation

Function

Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001760	aminocarboxymuconate-semialdehyde decarboxylase activity
GO:0003824	catalytic activity
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0046872	metal ion binding

Biological Process

GO:0008152	metabolic process
GO:0046874	quinolinate metabolic process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006992 Amidohydrolase 2

PFAM

PF04909

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0II68

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

515030

UniGene

Bt.21101

RefSeq

NP_001069162

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC122781

GenPept

AAI22782