Version 5.4
Bos taurus Gene: ACMSD
Summary
InnateDB Gene IDBG-642268.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACMSD
Gene Name 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008039
Encoded Proteins
IDBP-694709
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153086:
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:62692769-62753692
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010575 ENSBTAP00000010575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
GO:0046874 quinolinate metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000153086
View Gene Order
ENSMUSG00000026348
View Gene Order
Pathways
NETPATH
REACTOME
REACT_226362
Metabolism of amino acids and derivatives pathway
REACT_217639
Tryptophan catabolism pathway
REACT_219139
Metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_916
Tryptophan catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_240936
Tryptophan catabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
mmu00380
Tryptophan metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt Q0II68
TrEMBL
UniProt Splice Variant
Entrez Gene 515030
UniGene Bt.21101
RefSeq NM_001075694 XM_005202528
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122781
GenPept AAI22782
RNA Seq Atlas 515030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca