InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACTR3

Summary

InnateDB Protein

IDBP-694770.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTR3

Protein Name

Actin-related protein 3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004410

InnateDB Gene

IDBG-642313 (ACTR3)

Protein Structure

UniProt Annotation

Function

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). Cell projection. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0007163	establishment or maintenance of cell polarity
GO:0008356	asymmetric cell division
GO:0016344	meiotic chromosome movement towards spindle pole
GO:0030030	cell projection organization
GO:0033206	cytokinesis after meiosis
GO:0051321	meiotic cell cycle
GO:0051653	spindle localization
GO:0060271	cilium morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome