InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACTR3

Summary

InnateDB Gene

IDBG-642313.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTR3

Gene Name

Actin-related protein 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003401

Encoded Proteins

IDBP-694770

Actin-related protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115091:
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:65892592-65912704

Strand

Forward strand

Band

Transcripts

ENSBTAT00000004410

ENSBTAP00000004410

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0007163	establishment or maintenance of cell polarity
GO:0008356	asymmetric cell division
GO:0016344	meiotic chromosome movement towards spindle pole
GO:0030030	cell projection organization
GO:0033206	cytokinesis after meiosis
GO:0051321	meiotic cell cycle
GO:0051653	spindle localization
GO:0060271	cilium morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome