InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SIRT7

Summary

InnateDB Protein

IDBP-694785.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRT7

Protein Name

NAD-dependent deacetylase sirtuin-7

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000043

InnateDB Gene

IDBG-642335 (SIRT7)

Protein Structure

UniProt Annotation

Function

NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 616 interaction(s) predicted by orthology.

Predicted by orthology
Total	616 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0070403	NAD+ binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007072	positive regulation of transcription on exit from mitosis
GO:0009303	rRNA transcription
GO:0016568	chromatin modification
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005731	nucleolus organizer region
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF02146

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0P595

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

505662

UniGene

Bt.12071

RefSeq

NP_001068685

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120328

GenPept

AAI20329