Version 5.4
Bos taurus Gene: SIRT7
Summary
InnateDB Gene IDBG-642335.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT7
Gene Name NAD-dependent protein deacetylase sirtuin-7
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000039
Encoded Proteins
IDBP-694785
NAD-dependent deacetylase sirtuin-7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187531:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51585609-51591804
Strand Forward strand
Band
Transcripts
ENSBTAT00000000043 ENSBTAP00000000043
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 616 interaction(s) predicted by orthology.
Predicted by orthology
Total 616 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0070403 NAD+ binding
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007072 positive regulation of transcription on exit from mitosis
GO:0009303 rRNA transcription
GO:0016568 chromatin modification
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005731 nucleolus organizer region
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000187531
View Gene Order
ENSMUSG00000025138
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.12071
RefSeq NM_001075217
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca