Version 5.4
Bos taurus Protein: RAB8A
Summary
InnateDB Protein IDBP-694786.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB8A
Protein Name Ras-related protein Rab-8A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021408
InnateDB Gene IDBG-642338 (RAB8A)
Protein Structure
UniProt Annotation
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000250}. Recycling endosome membrane {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP- bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP- bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Localizes to tubular recycling endosome. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017137 Rab GTPase binding
GO:0019003 GDP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006904 vesicle docking involved in exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007409 axonogenesis
GO:0015031 protein transport
GO:0030030 cell projection organization
GO:0032869 cellular response to insulin stimulus
GO:0042384 cilium assembly
GO:0048210 Golgi vesicle fusion to target membrane
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0030140 trans-Golgi network transport vesicle
GO:0030670 phagocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031513 nonmotile primary cilium
GO:0036064 ciliary basal body
GO:0042995 cell projection
GO:0045335 phagocytic vesicle
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00071
PF00025
PF04670
PF08477
PRINTS PR00449
PR00627
PR00328
PIRSF
SMART SM00176
SM00174
SM00175
SM00173
SM00177
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4FV54
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 100125881
UniGene Bt.9871
RefSeq NP_001098951
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123755
GenPept AAI23756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca