InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RAB8A

Summary

InnateDB Gene

IDBG-642338.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB8A

Gene Name

Ras-related protein Rab-8A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000038696

Encoded Proteins

IDBP-694786

Ras-related protein Rab-8A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25022365

[Mus musculus] Rab8a interacts with Pik3cg to regulate Akt signalling generated by surface Tlr4.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167461:
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%%, 96%%, and 51%% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:7899037-7919167

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021408

ENSBTAP00000021408

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0017137	Rab GTPase binding
GO:0019003	GDP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006904	vesicle docking involved in exocytosis
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007409	axonogenesis
GO:0015031	protein transport
GO:0030030	cell projection organization
GO:0032869	cellular response to insulin stimulus
GO:0042384	cilium assembly
GO:0048210	Golgi vesicle fusion to target membrane
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0016020	membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0030670	phagocytic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0031513	nonmotile primary cilium
GO:0036064	ciliary basal body
GO:0042995	cell projection
GO:0045335	phagocytic vesicle
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome