Version 5.4
Bos taurus Protein: LDHA
Summary
InnateDB Protein IDBP-694881.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDHA
Protein Name L-lactate dehydrogenase A chain
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011447
InnateDB Gene IDBG-642426 (LDHA)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0021762 substantia nigra development
GO:0031668 cellular response to extracellular stimulus
GO:0044262 cellular carbohydrate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0035686 sperm fibrous sheath
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001236 Lactate/malate dehydrogenase, N-terminal
IPR001557 L-lactate/malate dehydrogenase
IPR011304 L-lactate dehydrogenase
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR022383 Lactate/malate dehydrogenase, C-terminal
PFAM PF00056
PF02866
PRINTS PR00086
PIRSF PIRSF000102
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P19858
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281274
UniGene Bt.3809
RefSeq NP_776524
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146210 D90141 D90142 D90143
GenPept AAI46211 BAA14169 BAA14170 BAA14171

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca