Version 5.4
| Bos taurus Protein: HGS | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Protein | IDBP-694951.2 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | HGS | ||||||||||||||||
| Protein Name | Hepatocyte growth factor-regulated tyrosine kinase substrate | ||||||||||||||||
| Synonyms | HRS; | ||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Protein | ENSBTAP00000000527 | ||||||||||||||||
| InnateDB Gene | IDBG-642467 (HGS) | ||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). {ECO:0000250}. | ||||||||||||||||
| Subcellular Localization | Cytoplasm. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endosome, multivesicular body membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. | ||||||||||||||||
| Disease Associations | |||||||||||||||||
| Tissue Specificity | |||||||||||||||||
| Comments | |||||||||||||||||
| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 134 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||
| PDB ID | |||||||||||||||||
| InterPro |
IPR000306
FYVE zinc finger IPR002014 VHS IPR003903 Ubiquitin interacting motif IPR008942 ENTH/VHS IPR011011 Zinc finger, FYVE/PHD-type IPR017073 Ubiquitin binding protein, Hrs/VPS27 IPR017455 Zinc finger, FYVE-related IPR018205 VHS subgroup IPR024641 Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain |
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| PFAM |
PF01363
PF00790 PF02809 PF12210 |
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| PRINTS | |||||||||||||||||
| PIRSF |
PIRSF036956
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| SMART |
SM00064
SM00726 SM00288 |
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| TIGRFAMs | |||||||||||||||||
| Post-translational Modifications | |||||||||||||||||
| Modification | |||||||||||||||||
| Cross-References | |||||||||||||||||
| SwissProt | Q0V8S0 | ||||||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||||||
| TrEMBL | |||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 511582 | ||||||||||||||||
| UniGene | Bt.6724 | ||||||||||||||||
| RefSeq | NP_001039554 | ||||||||||||||||
| HUGO | |||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | BC111313 BT026148 | ||||||||||||||||
| GenPept | AAI11314 ABG66987 | ||||||||||||||||