InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HGS

Summary

InnateDB Gene

IDBG-642467.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HGS

Gene Name

Hepatocyte growth factor-regulated tyrosine kinase substrate

Synonyms

HRS

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000411

Encoded Proteins

IDBP-694951

Hepatocyte growth factor-regulated tyrosine kinase substrate

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185359:
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:51733073-51746201

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000527

ENSBTAP00000000527

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 134 interaction(s) predicted by orthology.

Predicted by orthology
Total	134 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0015031	protein transport
GO:0046426	negative regulation of JAK-STAT cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0016020	membrane
GO:0031901	early endosome membrane
GO:0032585	multivesicular body membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome