InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NOTCH3

Summary

InnateDB Protein

IDBP-695022.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOTCH3

Protein Name

notch 3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053357

InnateDB Gene

IDBG-642521 (NOTCH3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0030900	forebrain development
GO:0045596	negative regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048663	neuron fate commitment
GO:0050793	regulation of developmental process
GO:0072104	glomerular capillary formation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000800 Notch domain
IPR001881 EGF-like calcium-binding domain
IPR002110 Ankyrin repeat
IPR008297 Notch
IPR010660 Notch, NOD domain
IPR011656 Notch, NODP domain
IPR013111 EGF-like domain, extracellular
IPR020683 Ankyrin repeat-containing domain
IPR022331 Neurogenic locus Notch 3
IPR024600 Domain of unknown function DUF3454, notch

PFAM